2010

  • O. Zerbe, Die molekularen Mechanismen des Sehens, book chapter in "Sinne", Ingrid Tomkowiak (Editor), Chronos Verlag 2010.

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2009

  • C. Zou, S. Kumaran, R. Walser, O. Zerbe, Properties of the N-terminal domains from Y receptors probed by NMR spectroscopy, J. Pept. Sci., 15, 184-191.
  • E. Peroza, R. Schmukli, P. Güntert, E. Freisinger, O. Zerbe, The βE-domain of wheat Ec-1metallothionein: A metal-binding domain with a distinctive structure, J. Mol. Biol., 387, 207-218.
  • N. Keller, J. Mares, O. Zerbe, M. Grütter, Structural and Biochemical Studies on Procaspase-8: New Insights on Initiator Caspase Activation, Structure,17, 438-448.
  • J. Mares, S. Kumaran, M. Gobbo, O. Zerbe, Interactions of lipopolysaccharide and polymyxin studied by NMR spectroscopy, J. Biol. Chem., 284, 11498-11506.
  • A. Neumoin, L. S. Cohen, B. Arshava, S. Tantry, J. Becker, O. Zerbe, F. Naider , Structure of a Double Transmembrane Fragment of a G Protein-Coupled Receptor in Micelles, Biophys. J., 96,3187-3196.
  • T. Zdobinsky, J. Scherkenbeck, O. Zerbe, Horst Antonicek, Structures of Micelle-Bound Selected Insect Neuropeptides and Analogues: Implications for Receptor Selection, ChemBioChem, 10, 2644-2653.
  • R. Maag, B.H. Northrop, A. Butterfield, A. Linden, O. Zerbe, Y.M. Lee, K-W. Chi, P.J. Stang, J.S. Siegel (2009), Synthesis and X-ray structural analysis of platinum and ethynyl-platinum corranulenes: spramolecular tectons, Org. Biolmol. Chem., 7, 4881–4885.

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2008

  • F. Parmeggiani, R. Pellarin, A. P. Larsen, G. Varadamshetty, O. Zerbe, A. Caflisch, A. Plückthun: Designed Armadillo Repeat Proteins as General Peptide Binding Scaffolds, J. Mol. Biol., 376,1282-1304.
  • L. S. Cohen, B. Arshava, R. Estephan, J. Englander, H. Kim, M. Hauser, O. Zerbe, M. Ceruso, J. M. Becker, F. Naider: Expression and biophysical analysis of two double-transmembrane domain-containing fragments from a yeast G protein-coupled receptor, Biopolymers Pept. Sci., 90, 117-130.
  • C. Zou, S. Kumaran, S. Markovic, R. Walser, O. Zerbe: Studies of the structure of the N-terminal domain from the Y4 receptor, a G-protein coupled receptor, and its interaction with hormones from the NPY family, ChemBioChem, 9, 2276-2284 (cover page).
  • C. Zou, F. Naider, O. Zerbe: Biosynthesis and NMR-Studies of a Double Transmembrane Domain from the Y4 Receptor, a Human GPCR, J. Biomol. NMR, 42, 257 - 269.
  • E.H.G. Backus, P.H. Nguyen, V. Botan, A. Moretto, M. Crisma, C. Toniolo, O. Zerbe, G. Stock, P. Hamm: Structural flexibility of a helical peptide regulates heat transport properties, J. Phys. Chem., 112, 15487–15492

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2007

  • M.C. Erat, O. Zerbe, T. Fox, R.K.O. Sigel: Solution Structure of Domain 6 from a Self-Splicing Group II Intron Ribozyme: A Mg2+ Binding Site is Located Close to the Stacked Branch Adenosine, ChemBioChem, 8, 306-314.
  • Neumoin, A., Arshava, B., Becker, J., Zerbe, O.*, Naider, F.*: NMR studies in DPC of a fragment containing the seventh transmembrane helix of a GPCR from Saccharomyces cerevisiae, Biophys. J., 93, 467-482.
  • Neumoin, A., Mares, J., Lerch-Bader, M., Bader, R., Zerbe, O.:Probing the Formation of Stable Tertiary Structure in a Model Miniprotein at Atomic Resolution: Determinants of Stability of a Helical Hairpin, J. Am. Chem. Soc., 129, 8811-8817.

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2006

  • R. Fasan, R.L.A. Dias, K. Möhle, O. Zerbe, D. Obrecht, P.E.R. Mittl, M.G. Grütter, J.A. Robinson: Structure-Activity Studies in a Family of beta-Haipin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction, ChemBioChem, 7, 515-526.
  • S. Jurt, A. Aemissegger, P. Güntert, O. Zerbe*, D. Hilvert*: A Photoswitchable Miniprotein Based on the Sequence of Avian Pancreatic Polypeptide, Angew. Chem. Int. Ed., 45, 6297-6300.
  • J. Mares, J.U. Müller, A. Skirgailiene, A. Neumoin, C.A. Bewley, R.R. Schmidt and O. Zerbe: A model for cell-surface exposed carbohydrate moieties suitable for structural studies by NMR, ChemBioChem,7, 1764-1773.
  • O. Zerbe, A. Neumoin, J. Mares, R. Walser and C. Zou: Recognition of Neurohormones of the NPY Family by their Receptors, J. Recept. Signal Tr. Res., 26, 487-504

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2005

  • N.Walch, T. Kühn, D. Moskau, O. Zerbe (2005) Strategies and Tools for Structure Determination of Natural Products Using Modern Methods of NMR Spectroscopy, Chemistry and Biodiversity, 2, 147-177.
  • M. Lerch, H. Kammimori, G. Folkers, M. Aguilar, A.G. Beck-Sickinger, O. Zerbe (2005) Strongly Altered Receptor Binding Properties in PP and NPY Chimera are Accompanied by Changes in Structure and Membrane Binding, Biochemistry, 44, 9255 - 9264.
  • R. Bader, O. Zerbe (2005) Are Hormones from the Neuropeptide Y Family Recognized by Their Receptors from the Membrane-Bound State?, ChemBioChem, 6, 1520-1534.
  • N. Pradeille, O. Zerbe, K., A. Linden, H. Heimgartner (2005), The First Total Synthesis of the Peptaibol Hypomurocin A1 and Its Conformation Analysis: an Application of the Azirine/Oxazolone Method, Chemistry and Biodiversity, 2, 1127-1152.
  • K. Weller, S. Lauber, M. Lerch, A. Renaud, H.P. Merkle & O. Zerbe(2005): Biophysical and Biological Studies of End-Group-Modified Derivatives of Pep-1, Biochemistry, 44,15799-15811.
  • M. Herbig, K. Weller, U. Krauss, A. G. Beck-Sickinger, H. P. Merkle & O. Zerbe(2005): Membrane surface associated helices promote lipid interactions and cellular uptake of human calcitonin-derived cell penetrating peptides, Biophys. J., 89, 4056-4066.

2004

  • S. De Pol, C. Zorn, C. Klein, O. Zerbe*, O. Reiser* (2004), Surprisingly Stable Helical Structures in altering a/b-Peptides by Incorporation of Cis-b-Aminocyclopropane Carboxylic Acids, Angew. Chem. Int. Ed., 43, 511-514.
  • R. Fasan, R.A.L. Dias, K. Möhle, O. Zerbe, J.W. Vrijbloed,D. Obrecht, J. Robinson (2004), Using a b-hairpin to mimic an a-helix: Novel cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction, Angew. Chem. Int. Ed., 43, 2109-2112.
  • M. Lerch, M. Mayrhofer, O. Zerbe (2004), Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide Y (NPY) are related to their affinity profiles at the Y receptors, J. Mol. Biol., 339, 1153-1168.
  • R. Bader, M. Lerch, O. Zerbe (2004) Protein Processing generates both physiologically and pathologically important peptides, PharmaChem, 3, 72-75.

In addition I have been serving as a section editor of Drug Discovery Today (DDT): Technologies for articles describe the use of NMR, Isothermal Titration Calorimetry, Metabonomics, Surface Plasmon Resonance and Analytical Ultracentrifugation for lead optimization, DDT: Technologies 1, 277-315 (on-line journal).

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2003

  • J. Scheuermann, A. Volonterio, O. Zerbe, M. Zanda, D. Neri (2003): Discovery and investigation of lead-compounds as binders to the Extra-Domain B of fibronectin, a marker of angiogenesis, Drug Discov. Res., 58, 268-282.
  • O. Zerbe (2003): New developments of NMR Techniques in Pharmaceutical Sciences, Newsmagazine of the American Association of Pharmaceutical Sciences, 6, 18-21.
  • Z. Dzolic, M. Cetina, D. Kovacek, A. Hergold-Brundic, D. Mrvos-Sermek, A. Nagl, N. Slade, K. Pavelic, J. Balzarini, E. De Clercq, O. Zerbe, G. Folkers, L. Scapozza, M. Mintas (2003), Molecular structures and ab initio molecular orbital calculations of the optically active derivatives of 1-aminocyclopropane-1-carboxylic acid, J. Mol. Struct., 655, 229




I have edited a book entitled “BioNMR Techniques in Drug Research” , published by Wiley. In this book, I have co-authored two chapters:

  • D. Moskau, O. Zerbe in BioNMR in Drug Research (Ed. O. Zerbe): Less Noise and Fewer Artifacts in NMR Spectra, pg. 67-78, Wiley-VCH, Weinheim 2002.
  • R. Bader, M. Lerch, O. Zerbe in BioNMR in Drug Research (Ed. O. Zerbe): NMR of Membrane-associated Peptides and Proteins, pg. 95-117, Wiley-VCH, Weinheim 2002.

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2002

  • Bader, R., Rytz, G., Beck-Sickinger, A.G., Zerbe, O. (2002): Key Motif to Gain Selectivity at the Neuropeptide Y5-Receptor: Structure and Dynamics of Micelle-Bound [Ala 31 ,Pro 32 ]-NPY, Biochemistry ,41 , 8031-8042.
  • Kaufmann, M., Bozic, D., Briand, C., Bodmer, J.-L., Zerbe, O., Kohl, A., Tschopp, J., Grütter, M.G. (2002): Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling,  FEBS Lett ., 527 , 250-254.
  • Akbay, P., Gertsch, J., Çal s, I., Heilmann, J., Zerbe, O., Sticher, O. (2002): Novel Antileukemic Sterol Glycosides from Ajuga salicifolia ,Helv. Chim. Acta ,85 , 1930-1942.
  • Lerch, M., Gafner, V., Bader, R., Christen, B., Folkers, G., Zerbe, O. (2002): Bovine pancreatic polypeptide (bPP) undergoes significant changes in conformation and dynamics upon binding to DPC micelles, J. Mol. Biol ., 322 , 1117-1133.
  • Romero-Isart, N., Jensen, L.T., Zerbe, O., Winge, D.R., Vasak, M. (2002): Engineering of Metallothionein-3 Neuroinhibitory Activity into the Inactive Isoform Metallothionein-1, J. Biol. Chem ., 277 , 37023-37028.
  • Shankaramma, S.C., Athanassiou, Z., Zerbe, O., Moehle, K., Mouton, C., Bernardini, F., Vrijbloed, J.W., Obrecht, D. and Robinson, J.A. (2002): Macrocyclic Hairpin Mimetics of the Cationic Antimicrobial Peptide Protegrin I: A New Family of Broad-Spectrum Antibiotics, ChemBioChem ,  3, 1126-1133.

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2001

  • Liu, A., Luginbühl, P., Zerbe, O., Ortenzi, C., Luporini, P., Wüthrich, K.(2001) : NMR structure of the pheromone Er-22 from Euplotes raikovi ,J. Biomol. NMR. ,19 ,  75-78.
  • Bader, R., Bettio, A., Beck-Sickinger, A., Zerbe, O. (2001): Structure and Dynamics of Micelle-bound Neuropeptide Y: Comparison with unligated NPY and Implications for Receptor Selection, J. Mol. Biol., 305, 307-329.
  • Rognan, D., Mukhija, S., Folkers, G., Zerbe, O. (2001): NMR-restrained docking of a peptide inhibitor to the N-terminal domain of the phosphoenolpyruvate:sugar phospotransferase enzyme1, J. Comp. Aid. Design, 15 , 103-115.
  • Jaki, B., Zerbe, O., Heilman, J.,  Sticher, O. (2001):Two Novel Cyclic Peptides with Antifungal Activity from the Cyanobactyerium Tolypothrix byssoida (EAWAG 195), J. Nat. Prod ., 64 , 154-158.
  • Winkelmann, K., Heilmann, J., Zerbe, O., Rali, T., Sticher, O. (2001):  New prenylated bi- and tricyclic phloroglucinol derivatives from Hypericum papuanum, J. Nat. Prod ., 64 , 701-706.
  • Demuth, C., Zerbe, O., Rognan, D., Soell, R., Beck-Sickinger, A.G., Folkers, G., Spichiger, U.E. (2001): A rationally designed oligopeptide shows significant conformational changes upon binding to sulphate ions, Biosensors & Bioelectronics ,16 , 783-789. 
  • Romero-Isart, N, Jensen, L.T., Zerbe, O., Vasak, M.(2001):  Engineering of metallothionein-3 neuronal activity into the inactive isoform metallothionein-1: Structural implications, J. Inorg. Biochem. 86 , 406 .
  • Winkelmann, K., Heilmann, J., Zerbe, O., Rali, T., Sticher, O. (2001):  Further prenylated bi- and tricyclic phloroglucinol derivatives from Hypericum papuanum, Helv. Chim. Act. 84 , 3380-92. 

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2000

  • Winkelmann, K., Heilmann, J., Zerbe, O., Sticher, O. (2000): New Phloroglucinol Derivatives from Hypericum papuanum, J. Nat. Prod. 63 , 104-108.
  • Blanco-Prieto, M.J., Besseghir, K., Zerbe,O., Andris, D., Orsolini, P., Heimgartner, F., Merkle, H.P., Gander, B. (2000): In vitro and in vivo evaluation of a somatostatin analogue released from PLGA microspheres, J. Contr. Rel. 67 , 19-28.
  • Bunke, A., Zerbe, O., Schmid, H., Burmeister, G., Merkle, H.P., Gander, B. (2000): Degradation mechanism and stability of 5-aminolevulinic acid, J. Pharm. Sci. 89, 1335-1341.
  • DeShong P., Soli E.D., Slough G.A. , Sidler D.R., Elango V., Rybczynski P.J., Vosejpka L.J.S., Lessen T.A., Le T.X., Anderson G.B., von Philipsborn W., Vohler M., Rentsch D., Zerbe O. (2000): Glycosylmanganese pentacarbonyl complexes: an organomanganese-based approach to the synthesis of C-glycosyl derivatives, J. Organomet. Chem.  594 ,  49-62.
  • Cabrele,  C., Langer,  M., Bader,  R., Wieland,  H.A.,  Doods,  H.,  Zerbe, O., Beck-Sickinger, A.G. (2000):The First Selective Agonist at the Neuropeptide Y Y5-Receptor Increases Food Intake in Rats, J. Biol. Chem .275 , 36043-36048 .
  • Hasler, D.W., Jensen, L.T., Zerbe, O., Wringe, D.R., Vasak, M. (2000): Effect of two conserved prolines of human growth inhibitory factor (GIF) on its structure and biological activity: comparison with a mutant protein, Biochemistry 39 , 14567-14575 .
  • Bader, R., Lerch, M., Folkers, G., Zerbe, O. (2000): Using Structural Information of Peptides, Derived from NMR Spectroscopy, in Pharmaceutical Chemistry, Chimia, 54 , 627-632.

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1999

  • Calis, I., Yusufoglu, H., Zerbe. O., Sticher, O. (1999), Cylocephaloside A: A tridesmosidic cycloartane type glycoside from Astragalus cephalotes var. brevicalyx ,Phytochemistry ,50 , 43-847.
  • Tasdemir, D., Scapozza, L., Zerbe, O., Linden, A., Calis, I. , Sticher, O. (1999): Iridoid Glycosides of Leonurus persicus .J. Nat. Prod .62 , 811-816.
  • Faller, P., Hasler, D., Zerbe, O., Klauser, S., Wringe, D.R., Vasak, M.(1999): Evidence for a Dynamic Structure of Human Neuronal Growth Inhibitory Factor and for Major Rearrangements of its Metal Thiolate Clusters. Biochemistry 38 , 10158 -10167 .
  • Bedir, E., Tasdemir, D., Zerbe, O., Calis, I. , Sticher, O. (1999):Neo-clerodane diterpenoids from Teucrium polium, Phytochemistry 51 , 921-925.
  • Faller, P., Hasler, D.W., Zerbe, O., Vasak, M. (1999): Dynamic structure of metal-thiolate clusters in neuronal growth inhibitory factor (GIF), J. Inorg. Biochem. 74 , 326.

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1998

  • Bedir, E., Calis, I. Zerbe. O., Sticher, O. (1998), Cylocephaloside I:A novel Cycloartane-Type Glycoside from Astragalus microcephalus, J. Nat. Prod ., 61 , 503-505.

1997

  • Ottiger, M., Zerbe, O., Güntert, P. & Wüthrich, (1997). The NMR solution conformation of unligated human cyclophilin A. J. Mol. Biol. ,272 , 64-81 .

1996

  • P. Luginbühl, J. Wu, O. Zerbe, C. Ortenzi, P. Luporini, K. Wüthrich (1996). The NMR solution structure of the pheromone E r-11 from the ciliated protozoan Euplotes raikovi .Prot. Sci. 5, 1512-1522.
  • O. Zerbe, T. Szyperski, M. Ottiger, K. Wüthrich (1996). Three-dimensional 1H-TOCSY-relayed ct-[ 13 C, 1H]-HMQC for aromatic spin system identification in uniformly 13 C-labelled proteins. J. Biomol. NMR 7, 99-106.
  • B. Rist, O. Zerbe, N. Ingenhoven, L. Scapozza, C. Peers, P.F.T. Vaughan, R.L. McDonald, H.A. Wieland, A.G. Beck-Sickinger (1996). Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y 2-receptor. FEBS Lett. 394 , 169-173.

1995

  • Y. Wang, E.A. Mackay, O. Zerbe, D. Hess, P.E. Hunziker, M. Vasak, J.H.R. Kägi (1995). Characterization and Sequential Localization of the Metal Clusters in Sea Urchin Metallothionein. Biochemistry , 7460-7467.
  • D.L. Pountney,O. Zerbe, W. v. Philipsborn, J.B. Egan, M. Vasak (1995). 3J( 113 Cd, 1H) Couplings in Cd(S-Cys) and Cd-u2(S-Cys)-Cd Moities follow a Karplus-like Dependence with the Hb-Cb-Sg-Cd Torsion Angle: Application to Protein Structure . Bull. J. Magn. Resonance 17 , 145-147.

1992-1994

  • J.H. Welsh, O. Zerbe, W. v. Philipsborn, J.A. Robinson (1992). beta-Turns Induced in Bradykinin by (S)-alpha-Methylproline FEBS Lett. 297 , 216-220.
  • O. Zerbe, J.H. Welsh, J.A. Robinson, W. v. Philipsborn (1992). Complete Assignment of the 1H, 13 C and 15 N Spectra of Bradykinin Derivatives Magn. Reson. Chem. 30, 683-685.
  • O. Zerbe, J.H. Welsh, J.A. Robinson, W. von Philipsborn (1992). A 13 C and 15 N Edited Triple Resonance Experiment. J. Magn. Reson. 100, 329-335.
  • P. DeShong, T.A. Lessen, T.X. Le, G. Anderson, R. Sidler, G.A. Slough, W. v. Philipsborn, M. Vöhler, O. Zerbe (1993). Glycosylmanganese Complexes and Anomeric Anomalies. The next Generation? in: ACS Symposium Series: The Anomeric Effect and Associated Stereoelectronic Effects . Chapt. 12. 227-239.
  • P. Palumaa, O. Zerbe, M. Vasak (1993). Formation and Spectroscopic Characterization of a Novel Monomeric Cadmium-Containing and Phosphate-Containing Form of Metallothionein. Biochemistry 32, 2874-2879.
  • C.J. Henehan, D.L. Pountney, O. Zerbe, M. Vasak (1993). Identification of Cysteine Ligands in Metalloproteins Using Optical and NMR Spectroscopy: Cadmium-Substitued Rubredoxin as a Model [Cd(CysS) 4]2- Center. Prot. Sci. 2, 1756-1764.
  • O. Zerbe, D.L. Pountney, W. v. Philipsborn, M. Vasak (1994). The Magnitude of the Heteronuclear Vicinal Cysteine 1Hb-113 Cd Coupling follows a Karplus-Type Dependence. J. Am. Chem. Soc. 116, 377.
  • M.J. Blommers, D. Nanz, O. Zerbe (1994). Determination of the backbone torsion angle epsilon in nucleis acids. J. Biomol. NMR 4, 595-601.
  • A. Baumeler, O. Zerbe, R.W. Kunz, C.H. Eugster (1994). (6R,9'Z)-Neoxanthin: Synthese, Schmelzverhalten, Spektren und Konformationsberechnungen. Helv. Chim. Acta 77, 909-930.

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last modified: 12.11.09 (oz)