Selected References:

PubMed link to the selected publications

Komisarski M, Osornio YM, Siegel JS, Landau EM. Tailored Host-Guest Lipidic Cubic Phases: A Protocell Model Exhibiting Nucleic Acid Recognition. Chemistry. 2013 Jan 21;19(4):1262-7. doi: 10.1002/chem.201203372.

Osornio YM, Uebelhart P, Bosshard S, Konrad F, Siegel JS, Landau EM. Design and synthesis of lipids for the fabrication of functional lipidic cubic-phase biomaterials. J Org Chem. 2012 Dec 7;77(23):10583-95. doi: 10.1021/jo301659c.

Qutub Y, Reviakine I, Maxwell C, Navarro J, Landau EM, Vekilov PG. Crystallization of transmembrane proteins in cubo: mechanisms of crystal growth and defect formation. J Mol Biol. 2004 Nov 5;343(5):1243-54.

Landau EM, Pebay-Peyroula E, Neutze R. Structural and mechanistic insight from high resolution structures of archaeal rhodopsins. FEBS Lett. 2003 Nov 27;555(1):51-6.

Paas Y, Cartaud J, Recouvreur M, Grailhe R, Dufresne V, Pebay-Peyroula E, Landau EM, Changeux JP. Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matrices. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11309-14.

Neutze R, Pebay-Peyroula E, Edman K, Royant A, Navarro J, Landau EM. Bacteriorhodopsin: a high-resolution structural view of vectorial proton transport. Biochim Biophys Acta. 2002 Oct 11;1565(2):144-67.

Okada T, Fujiyoshi Y, Silow M, Navarro J, Landau EM, Shichida Y. Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.  Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5982-7.

Nollert P, Navarro J, Landau EM. Crystallization of membrane proteins in cubo. Methods Enzymol. 2002;343:183-99.

Royant A, Nollert P, Edman K, Neutze R, Landau EM, Pebay-Peyroula E, Navarro J. X-ray structure of sensory rhodopsin II at 2.1-A resolution. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10131-6.  

Pebay-Peyroula E, Neutze R, Landau EM. Lipidic cubic phase crystallization of bacteriorhodopsin and cryotrapping of intermediates: towards resolving a revolving photocycle. Biochim Biophys Acta. 2000 Aug 30;1460(1):119-32.

Royant A, Edman K, Ursby T, Pebay-Peyroula E, Landau EM, Neutze R. Helix deformation is coupled to vectorial proton transport in the photocycle of bacteriorhodopsin. Nature. 2000 Aug 10;406(6796):645-8.

Edman K, Nollert P, Royant A, Belrhali H, Pebay-Peyroula E, Hajdu J, Neutze R, Landau EM. High-resolution X-ray structure of an early intermediate in the bacteriorhodopsin photocycle. Nature. 1999 Oct 21;401(6755):822-6.

Pebay-Peyroula E, Rummel G, Rosenbusch JP, Landau EM. X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases. Science. 1997 Sep 12;277(5332):1676-81.

Landau EM, Rosenbusch JP. Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14532-5.